Probiotic Strains
Development

Platform

A functional probiotic integration development platform was established through collaboration between Bened and the Microbiome Research Center at NYMU. Bened has already found and preserved thousands of probiotic strains which were isolated from fermented food, infant excrement, and breast milk. Based on various cellular models and animal models, we sifted numerous probiotics exhibiting special physiological activities and investigated their safety and specific functions such as anti-allergy, immunomodulation, anti-pathogen, anti-aging, sleeping, Irritable bowel syndrome (IBS), Inflammatory Bowel Disease (IBD), chronic fatigue, early life stress, chronic stress, Parkinson’s disease (PD), Tourette syndrome (TS), Autism (ASD), etc.



Patent Portfolio

Probiotic Species Function Patent
Psycho-neurological Lactobacillus plantarum Depression, IBS, Mobility, Anti-inflammation 18 countries

(incl. TW, US, EU, JP, etc.)

Metabolic
Maintenance
Lactobacillus plantarum Anti-inflammation, Weight Control, Reduce Body Fat,Reduce Cholesterol and Triglyceride Level TW, US, CN, HK
Immune-modulation Lactococcus lactis Anti-Allergy TW, US
Lactobacillus plantarum Anti-Allergy, Anti-Asthma TW, US, CN
Lactobacillus paracasei Anti-Allergy TW
Oral Health Lactobacillus salivarius Anti-Cavities TW

PsychoBiotics

The experimental animal study indicates chronic administration of Lactobacillus plantarum PS128 significantly ameliorates anxiety and depression-like behaviors, increases dopaminergic activity in the prefrontal cortex, and reduced stress-induced elevation of serum corticosterone and inflammatory cytokine levels in mice subjected to early maternal separation. Oral administration with Lactobacillus plantarum PS128 significantly decreases visceral hypersensitivity in a rat animal model. Lactobacillus plantarum PS128 shows potential for irritable bowel syndrome (IBS) treatment.

ImmunoBiotics

In vitro experiment reveals cytokines IFN-γ production by human peripheral blood mononuclear cells stimulated with Lactococcus lactis A17 is higher compared with those with other 17 Lactic acid bacteria strains, including Lactobacillus rhamnosus GG and Lactobacillus casei strain Shirota. The Ovalbumin (OVA)-sensitized BALB/c mouse model was further conducted to further examine the Immunomodulatory activities of A17. Repression of NOD-1, NOD-2, TLR-4 production

MetabolicBiotics

Supplementation of Lactobacillus plantarum K21 appeared to alleviate body weight gain and epididymal fat mass accumulation, reduce plasma leptin levels, decrease cholesterol and triglyceride levels, and mitigate liver damage in diet-induced obese mice. In addition, Lactobacillus plantarum K21 supplementation strengthens intestinal permeability and modulates the amount of Lactobacillus spp., Bifidobacterium spp., and Clostridium perfringens in the cecal contents of diet-induced obese mice. Dietary intake of Lactobacillus plantarum K21 does protect against the onset of high-fat diet induced obesity through multiple mechanisms of action.