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Effects of PS128® on Parkinsonian Symptoms

2018 / 10 / 02
 
Brief Summary:
The purpose of this study is to examine the short term effects (12 Weeks) of Lactobacillus plantarum PS128® (PS128®) on Parkinson's disease (PD) symptoms.

 

Condition or disease  Intervention/treatment  Phase 
Parkinson Disease Dietary Supplement: Lactobacillus plantarum

PS128®

Not Applicable


Detailed Description:
This study is designed to examine the extent to which L. plantarum PS128® can improve symptoms in PD patients. L. plantarum PS128® is a psychobiotic that regulates the level of dopamine in specific brain regions. Patients with PD will receive PS128® treatment for 12 weeks. Symptoms of PD will be clinically evaluated before and after the treatment, and the results will be compared.
 
 
Outcome Measures
 
Primary Outcome Measures 
  1. Change in Unified Parkinson's Disease Rating Scale (UPDRS) Score From Baseline to Change in Unified Parkinson's Disease Rating Scale (UPDRS) (Part III) Motor Score From Baseline to Week 12 Assessed On Medication [ Time Frame: Baseline to Week 12 ]
    The UPDRS scores is a rating tool used to gauge the course of Parkinson's disease in patients. The minimum total score possible is 0 and the maximum total score possible is 199. Higher values represent a worse outcome.
 
Secondary Outcome Measures 
  1. Change in Nonmotor Symptoms: 30-item Screening Questionnaire (NMS-Quest) Score From Baseline to Week 12 Assessed On Medication [ Time Frame: to Week 12 Assessed On Medication ]
    NMS-Quest is a 30-item Screening tool for non-motor symptoms of Parkinson's disease. The minimum total score possible is 0 and the maximum total score possible is 30. Higher values represent a worse outcome.
  2. Change in Patient Global Impression of Change (PGIC) Score From Baseline to Week 12 Assessed On Medication [ Time Frame: to Week 12 Assessed On Medication ]
    The PGIC consists of one item taken from the clinical global impression and adapted to the patient. The minimum total score possible is 1 and the maximum total score possible is 7. Higher values represent a worse outcome.